Sodium Acetate → HCID 131734533, compound

HRID 591545Notes

Reaction equation

HRID 591545 reaction equation
[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:3]=1[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:9]2[C:10](=O)[CH2:11][O:12][C:8]=2[CH:7]=1.C([O-])(=O)C.[Na+].Cl.[CH3:27][O:28][NH2:29]>CO>[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:3]=1[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:9]2[C:10](=[N:29][O:28][CH3:27])[CH2:11][O:12][C:8]=2[CH:7]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 46299459HCID 46299459, compound

Product 1

HCID 131734533HCID 131734533, compoundYield 56.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 6-(2,4-dichlorobenzyloxy)benzofuran-3(2H)-one (2.0 g) in MeOH (20 mL) were added sodium acetate (0.531 g) and O-methylhydroxylamine hydrochloride (0.540 g). The mixture was refluxed overnight. After cooling, the mixture was concentrated. The residue was washed with water and EtOAc to give the title compound (1.24 g).

Workup

  1. temperatureThe mixture was refluxed overnight
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated
  4. washThe residue was washed with water and EtOAc

Sources & evidence

ORD record
ord-4c8a0577c9b64a75967872df27ddf4bc
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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