反应详情

A mixture of anisole (12.04 g), 1-fluoro-3-methoxy-5-((4-methoxybenzyl)sulfanyl)benzene (6.2 g) and TFA (20 mL) was refluxed for 1 h, then concentrated in vacuo. Water was added to the residue and the mixture was extracted with EtOAc. The organic layer was washed with saturated aqueous NaHCO3 and extracted with 2N NaOH (100 mL×3). The water layer was acidified with 6N HCl and extracted with EtOAc. The EtOAc extract was washed successively with water and brine, dried over MgSO4, and concentrated in vacuo to give the title compound (2.30 g).

1. temperaturewas refluxed for 1 h
2. concentrationconcentrated in vacuo
3. additionWater was added to the residue
4. extractionthe mixture was extracted with EtOAc
5. washThe organic layer was washed with saturated aqueous NaHCO3
6. extractionextracted with 2N NaOH (100 mL×3)
7. extractionextracted with EtOAc
8. extractionThe EtOAc extract
9. washwas washed successively with water and brine
10. dry with materialdried over MgSO4
11. concentrationconcentrated in vacuo