Trifluoroacetic acid → HCID 89738583, compound

HRID 592055Notes

Reaction equation

HRID 592055 reaction equation
[C:1]([C@H:4]1[C@H:9]2[O:10][C@H:6]([CH2:7][CH2:8]2)[C@H:5]1[NH:11]C(=O)OC(C)(C)C)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:11][C@@H:5]1[C@@H:6]2[O:10][C@@H:9]([CH2:8][CH2:7]2)[C@@H:4]1[C:1]([NH2:2])=[O:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117717655HCID 117717655, compound

Product 1

HCID 89738583HCID 89738583, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl(1R,2S,3R,4S)-3-carbamoyl-7-oxabicyclo[2.2.1]heptan-2-ylcarbamate (14) (40 mg, 0.156 mmol) was taken in DCM and cooled to 0° C. when TFA (10 eq) was added and the reaction mixture was then stirred at rt for 3-4 h when TLC confirmed completion of reaction. TFA was removed and afforded the product (40 mg, quantitative) as a yellow oil.

Workup

  1. additionwas added
  2. customcompletion of reaction
  3. customTFA was removed
  4. customafforded the product (40 mg, quantitative) as a yellow oil

Sources & evidence

ORD record
ord-c3d10b91cd404ca1b2abe96a61f6f1e1
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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