Diethyl Ether → tert-Butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

HRID 592358Notes

Reaction equation

HRID 592358 reaction equation
CCOCC.Cl[C:7]1[N:12]=[C:11]([Cl:13])[C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][N:8]=1.[NH2:18][C:19]1[CH:20]=[N:21][N:22]([CH:24]2[CH2:29][CH2:28][N:27]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:26][CH2:25]2)[CH:23]=1.CCN(CC)CC>CC(O)(C)C.ClCCCl.[Cl-].[Cl-].[Zn+2]>[Cl:13][C:11]1[C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][N:8]=[C:7]([NH:18][C:19]2[CH:20]=[N:21][N:22]([CH:24]3[CH2:25][CH2:26][N:27]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:28][CH2:29]3)[CH:23]=2)[N:12]=1

Participants

8

Reactant 4

HCID 3283Diethyl EtherHCID 8471TriethylamineHCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidineHCID 27281520tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 86712281tert-Butyl 4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Reagents, catalysts & solvents 3

HCID 3007855ZincchlorideCatalystHCID 111,2-DichloroethaneSolvent2×HCID 6386tert-ButanolSolvent2×

Procedure

A 1.0 M solution of ZnCl2 in Et2O (22.5 mL, 22.5 mmol) was added to a solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine (4.48 g, 20.7 mmol) in t-BuOH (50 mL) and DCE (50 mL) and the mixture was stirred for 10 minutes. The mixture was diluted with t-BuOH (50 mL) and DCE (50 mL) before tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate (5.00 g, 18.8 mmol) and Et3N (3.14 mL, 22.5 mmol) were added. Stirring was continued overnight and the volatiles were subsequently removed in vacuo. The resultant residue was suspended in acetone (50 mL) then water (500 mL) and sonicated for 15 minutes before the solid was removed by vacuum filtration and the filter cake washed with water (100 mL). The solid was suspended in acetone (25 mL), filtered and the filter cake was washed with petroleum benzine 40-60° C. (200 mL) to give the title compound K8 as a light pink solid (6.57 g, 78%). LCMS-D: rt 3.618 min; m/z 445.1 [M−H]−.

Workup

  1. additionwere added
  2. stirringStirring
  3. waitwas continued overnight
  4. customthe volatiles were subsequently removed in vacuo
  5. customwater (500 mL) and sonicated for 15 minutes before the solid
  6. customwas removed by vacuum filtration
  7. washthe filter cake washed with water (100 mL)
  8. filtrationfiltered
  9. washthe filter cake was washed with petroleum benzine 40-60° C. (200 mL)

Sources & evidence

ORD record
ord-ab16ab0db26040e691d0421d4e0843eb
Source dataset
uspto-grants-2016_01
Patent number
US09238644B2

Reaction notes

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