反应详情

温度

120 °C

A mixture of 2-(2-(2-(5-chloro-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-ylethyl)phenyl)propanamide A30 (0.080 g, 0.25 mmol), 5-aminopyrimidine (0.047 g, 0.49 mmol), Xantphos (0.0057 g, 0.010 mmol) and Cs2CO3 (0.24 g, 0.74 mmol) in 1,4-dioxane (3 mL) was bubbled with nitrogen for 10 minutes. Palladium (II) acetate (0.0011 g, 0.0049 mmol) was added and the mixture was heated at 120° C. under microwave irradiation for 20 minutes. The volatiles were removed in vacuo and the residue was purified by silica gel column chromatography (Combiflash Rf, 0-10% MeOH in DCM) to give the title compound 40 as an off white solid (0.030 g, 32%). LCMS-C: rt 4.85 min; m/z 383 [M+H]+.

1. customwas bubbled with nitrogen for 10 minutes
2. customThe volatiles were removed in vacuo
3. customthe residue was purified by silica gel column chromatography (Combiflash Rf, 0-10% MeOH in DCM)