反应详情

A solution of the product of Example 3, Step B (0.2 g, 0.69 mmol), N-bromosuccinimide (117 mg, 166 mmol) and a catalytic amount of AIBN in 2 ml CCl4 was refluxed for 30 minutes. The reaction mixture was concentrated in vacuo and chromatographed on silica gel (125×20 mm) eluting with 5% ethyl acetate in hexane. The product was isolated in a 73% yield (186 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customchromatographed on silica gel (125×20 mm)
3. washeluting with 5% ethyl acetate in hexane
4. customThe product was isolated in a 73% yield (186 mg)