Oxalyl chloride → 2-Chloro-6-iodobenzoyl isocyanate

HRID 59286Notes

Reaction equation

HRID 59286 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 716509022-Chloro-6-iodobenzamide

Product 1

HCID 900191152-Chloro-6-iodobenzoyl isocyanateYield 92.9%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 2-chloro-6-iodobenzamide (1.0 g, 3.5 mmol), oxalyl chloride (0.538 g, 4.2 mmol) and EDC (20 mL) to afford 1.00 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-af25b366247a4c7385575c56798c0f20
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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