Oxalyl chloride → 2-Fluoro-4-iodobenzoyl isocyanate

HRID 59323Notes

Reaction equation

HRID 59323 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[F:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 219047552-Fluoro-4-iodobenzamide

Product 1

HCID 900186562-Fluoro-4-iodobenzoyl isocyanateYield 66.8%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 2-fluoro-4-iodobenzamide (0.500 g, 1.8 mmol), oxalyl chloride (0.285 g, 2.2 mmol) and EDC (10 mL) to afford 0.350 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-8be57fe82687435dab17b71d68e9f4bb
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

Loading…