反应详情

Malimidopropionic acid (500 mg) was dissolved in dry THF (15 ml). TSTU (790 mg) and DIPEA (0.62 ml) was added. The mixture was stirred at room temperature under nitrogen over night. The yellow thick suspension was concentrated. The residue was dissolved in DCM and extracted with 0.1 N HCl (2×) and brine (1×). The organic layer was dried (Na2SO4) and concentrated to give a white solid. LC-MS, M/z: 267.26 (M+1).

1. concentrationThe yellow thick suspension was concentrated
2. dissolutionThe residue was dissolved in DCM
3. extractionextracted with 0.1 N HCl (2×) and brine (1×)
4. dry with materialThe organic layer was dried (Na2SO4)
5. concentrationconcentrated
6. customto give a white solid