Ammonia → 3-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

HRID 59354Notes

Reaction equation

HRID 59354 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10](O)=[O:11])=[O:4].C(Cl)(=O)C(Cl)=O.[NH3:26]>C1COCC1>[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10]([NH2:26])=[O:11])=[O:4]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 866922272,6-Dimethyl-3-((2,2,2-trifluoroacetamido)methyl)benzoic acid

Product 1

HCID 900191333-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 3-((2,2,2-trifluoroacetamido)methyl)-2,6-dimethylbenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-af0e292915e14969a20ac42f8ad78e43
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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