Pivaloyl chloride → N-(3-amino-4-chlorobenzyl)pivalamide

HRID 59398Notes

Reaction equation

HRID 59398 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:10])=[C:7]([NH2:9])[CH:8]=1.[C:11](Cl)(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]>C1COCC1>[NH2:9][C:7]1[CH:8]=[C:3]([CH:4]=[CH:5][C:6]=1[Cl:10])[CH2:2][NH:1][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 134650975-(Aminomethyl)-2-chloroaniline

Product 1

HCID 66765386N-(3-amino-4-chlorobenzyl)pivalamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-83 by using 5-(aminomethyl)-2-chlorobenzenamine (2.0 g), pivaloyl chloride (0.2 mL), TEA (2 mL) and THF (10 mL) to afford 2.0 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-a8099ef99c6b4d1a898bda7d09d150ba
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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