Oxalyl chloride → 4-(Bromomethyl)benzoyl isocyanate

HRID 59409Notes

Reaction equation

HRID 59409 reaction equation
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:9]=[C:13]=[O:14])=[O:8])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 5842164-(bromomethyl)benzamide

Product 1

HCID 900189974-(Bromomethyl)benzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-(bromomethyl)benzamide (0.200 g), oxalyl chloride (0.012 mL) and EDC (15 mL) to afford 0.150 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-407fd253c6b44db9b13486776b9d965c
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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