Oxalyl chloride → 4-(5-Isopropyl-1,3,4-oxadiazol-2-yl)benzoyl isocyanate

HRID 59411Notes

Reaction equation

HRID 59411 reaction equation
[CH:1]([C:4]1[O:8][C:7]([C:9]2[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=2)=[N:6][N:5]=1)([CH3:3])[CH3:2].C(Cl)(=O)[C:19](Cl)=[O:20]>C(Cl)CCl>[CH:1]([C:4]1[O:8][C:7]([C:9]2[CH:17]=[CH:16][C:12]([C:13]([N:15]=[C:19]=[O:20])=[O:14])=[CH:11][CH:10]=2)=[N:6][N:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 90027995HCID 90027995, compound

Product 1

HCID 900275314-(5-Isopropyl-1,3,4-oxadiazol-2-yl)benzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-(5-isopropyl-1,3,4-oxadiazol-2-yl)benzamide (0.200 g), oxalyl chloride (0.012 mL) and EDC (15 mL) to afford 0.150 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-11ff189a84314f5db0c6ed259e78d1bf
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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