Methanol → HCID 61147895, compound

HRID 594199Notes

Reaction equation

HRID 594199 reaction equation
[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[CH:4][CH:3]=1.CO>O1CCCC1.[Pt].[C]>[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[N:8]=[CH:9][C:10]([NH2:13])=[CH:11][N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 61147515HCID 61147515, compound

Product 1

HCID 61147895HCID 61147895, compoundYield 101%

Reagents, catalysts & solvents 2

HCID 178503042HCID 178503042, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Under an argon atmosphere, to a solution of 2-(4-bromophenoxy)-5-nitropyrimidine (400 mg) in tetrahydrofuran (20 mL)/methanol (20 mL) was added 3% platinum-carbon (200 mg). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered through Celite® to give the titled compound (363 mg) having the following physical data.

Workup

  1. filtrationThe reaction mixture was filtered through Celite®

Sources & evidence

ORD record
ord-f367567c98684bd99758d6ed22449b00
Source dataset
uspto-grants-2016_01
Patent number
US09242977B2

Reaction notes

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