Diethyl Ether → 2-Bromo-1-ethoxy-3-fluorobenzene

HRID 594356Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594356
[Br:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].I[CH2:11][CH3:12].C([O-])([O-])=O.[K+].[K+].CCOCC>CN(C=O)C>[Br:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH2:11][CH3:12]

Komponenten

6

Edukt 4

HCID 3283Diethyl EtherHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 121757012-Bromo-3-fluorophenol

Produkt 1

HCID 690823742-Bromo-1-ethoxy-3-fluorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of commercially available 2-bromo-3-fluorophenol (5.000 g; 26.20 mmol), iodoethane (8.166 g; 52.40 mmol), and K2CO3 (4.342 g; 31.40 mmol) in anh. DMF (100 ml) was heated to 80° C., under nitrogen, for 1.5 h. Et2O was added and the organic layer was washed with water, dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure affording 2-bromo-1-ethoxy-3-fluorobenzene as a yellow oil. LC-MS (conditions A): tR=0.88 min.; no ionisation.

Aufarbeitung

  1. washthe organic layer was washed with water
  2. dry with materialdried over anh. MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-139c03e8591141bb9ad5969c5fea0cdf
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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