Bromomethylcyclopropane → HCID 69081956, compound

HRID 594627Notes

Reaction equation

HRID 594627 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH:10]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]1.Br[CH2:30][CH:31]1[CH2:33][CH2:32]1>>[CH:33]1([CH2:32][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=2[CH:10]2[N:15]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:25])[F:26])=[CH:19][CH:18]=3)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 69083694HCID 69083694, compound

Product 1

HCID 69081956HCID 69081956, compound

Procedure

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2-hydroxy-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one with commercially available (bromomethyl)cyclopropane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.86 min.; [M+H]+: 449.76 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-52756248d1614712be81a26378b1ffba
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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