2-Bromoethyl methyl ether → HCID 69084618, compound

HRID 594628Notes

Reaction equation

HRID 594628 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH:10]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]1.Br[CH2:30][CH2:31][O:32][CH3:33]>>[CH3:9][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:1][CH2:30][CH2:31][O:32][CH3:33])[C:3]=1[CH:10]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:25])[F:26])=[CH:19][CH:18]=2)[C:14](=[O:28])[CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 69083694HCID 69083694, compound

Product 1

HCID 69084618HCID 69084618, compound

Procedure

Prepared according to the described general procedure 7 (GP7) by O-alkylation of 6-(2-hydroxy-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one with commercially available 1-bromo-2-methoxyethane. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 454.25 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-6d9fd63eb0524c0ba78fb74ea8c2c5fa
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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