Hydrochloric Acid → N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

HRID 594958Notes

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[CH:4]=[N:3]1.Cl[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[CH:17][C:12]2=[CH:11][N:10]=1.Cl>C(O)(C)C>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:9]2[N:14]=[C:13]3[NH:15][N:16]=[CH:17][C:12]3=[CH:11][N:10]=2)[CH:4]=[N:3]1

Participants

Conditions

Temperature: 140 °C

Procedure

A suspension of 1-methyl-1H-pyrazol-4-amine (173 mg, 1.29 mmol), 6-chloro-1H-pyrazolo[3,4-d]pyrimidine (200 mg, 1.29 mmol) and HCl (25 μL, 4M in dioxane) in isopropanol (2 mL) was heated in the microwave at 140° C. for 1 h. After cooling to rt, the mixture was filtered and the resulting solid washed with cold isopropanol and diethyl ether to give N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine.

Workup

temperatureAfter cooling to rt
filtrationthe mixture was filtered
washthe resulting solid washed with cold isopropanol and diethyl ether

Sources & evidence

ORD record: ord-8115ee6c24534ecb842ba021ead9b8a8
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09242987B2

Reaction notes

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