2-Bromoethanol → 4-Amino-1H-imidazole-1-ethanol

HRID 595008Notes

Reaction equation

HRID 595008 reaction equation

[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-])=O.Br[CH2:10][CH2:11][OH:12]>CN(C=O)C>[NH2:1][C:4]1[N:5]=[CH:6][N:7]([CH2:10][CH2:11][OH:12])[CH:8]=1

Participants

4

Reactant 2

HCID 108982-Bromoethanol

HCID 178526856HCID 178526856, compound

Product 1

HCID 230645694-Amino-1H-imidazole-1-ethanol

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(4-amino-1H-imidazol-1-yl)ethanol was prepared by Procedure A using 4-nitro-1H-imidazole and 2-bromoethanol in DMF instead of ACN.

Sources & evidence

ORD record: ord-eab4a5beb5da4d3aaa2f17e90c0e52af
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09242987B2

Reaction notes

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