Acetic Acid → HCID 89494565, compound

HRID 595063Notes

Reaction equation

HRID 595063 reaction equation
C(S[C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH:12]([CH3:13])[S:11][CH2:10][C:8]=2[N:9]=1)C.C(O)(=[O:17])C>Cl>[CH3:13][CH:12]1[C:7]2[C:6](=[O:14])[NH:5][C:4](=[O:17])[NH:9][C:8]=2[CH2:10][S:11]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 136506161HCID 136506161, compound

Product 1

HCID 89494565HCID 89494565, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-(ethylthio)-5-methylthieno[3,4-d]pyrimidin-4(3H,5H,7H)-one (4.0 g, 17.5 mmol), was suspended in 4.0 mL of conc. HCl and 6.0 mL of glacial acetic acid and the suspension heated at reflux overnight. The mixture was cooled and the precipitated solid collected by filtration, washed with water, and dried to provide 5-methylthieno[3,4-d]pyrimidine-2,4(1H,3H,5H,7H)-dione as a white solid (3.20 g, 100%).

Workup

  1. temperatureat reflux overnight
  2. temperatureThe mixture was cooled
  3. filtrationthe precipitated solid collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-bf5a47d971f24203b4a49088c7102802
Source dataset
uspto-grants-2016_01
Patent number
US09242993B2

Reaction notes

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