Potassium Carbonate → HCID 118046715, compound

HRID 595878Notes

Reaction equation

HRID 595878 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([CH2:9][CH2:10][C:11]([O:13]C)=[O:12])=[N:6][C:7]=1[Br:8].C(=O)([O-])[O-].[K+].[K+].[O-]S([O-])(=O)=O.[Na+].[Na+]>CO.O.CCOC(C)=O>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[N:6][C:7]=1[Br:8]

Participants

7

Reactant 3

HCID 11430Potassium CarbonateHCID 24436Sodium SulfateHCID 118045699HCID 118045699, compound

Product 1

HCID 118046715HCID 118046715, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of methyl 3-(5-amino-6-bromopyrazin-2-yl)propanoate (55 mg, 0.211 mmol) in MeOH (961 μL) and H2O (96 μL) was added potassium carbonate (170 mg, 1.230 mmol). The reaction mixture was stirred for overnight. To the reaction mixture, anhydrous Na2SO4 was added. After diluted with EtOAc (3 mL) and filtered, the volatile materials were removed in vacuo. The crude 3-(5-amino-6-bromopyrazin-2-yl)propanoic acid was obtained and used for the next step without further purification. LCMS (m/z): 246.0/248.0 (MH+, major), 0.26 min.

Workup

  1. filtrationfiltered
  2. customthe volatile materials were removed in vacuo

Sources & evidence

ORD record
ord-67c3649811164d9fb141e88cc0430217
Source dataset
uspto-grants-2016_01
Patent number
US09242996B2

Reaction notes

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