Triethylamine → HCID 20326657, compound

HRID 596176Notes

Reaction equation

HRID 596176 reaction equation
[CH2:1]([O:3][CH:4]([O:23][CH2:24][CH3:25])[CH2:5][O:6][C:7]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:8][CH2:9][NH2:10])[CH3:2].C(N(CC)CC)C.[CH:33]1([C:36](Cl)=[O:37])[CH2:35][CH2:34]1>C(Cl)Cl>[CH2:24]([O:23][CH:4]([O:3][CH2:1][CH3:2])[CH2:5][O:6][C:7]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:9][NH:10][C:36]([CH:33]1[CH2:35][CH2:34]1)=[O:37])[CH3:25]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 20326633HCID 20326633, compound

Product 1

HCID 20326657HCID 20326657, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

The starting material is prepared as follows. The solution of 3.4 g of 2-(3-amino-1,1-diphenylpropoxy)-acetaldehyde diethyl acetal, 1.5 g of triethylamine and 35 ml of methylene chloride is stirred and cooled in an ice bath during the dropwise addition of the solution of 1.05 g of cyclopropane carboxylic acid chloride in 15 ml of methylene chloride. Upon stirring subsequently for 1/2 hour at 0°-5° C, the solution is washed successively with 2N aqueous sodium hydroxide and saturated aqueous sodium chloride, dried and evaporated, to yield the 2-(3-cyclopropylcarbonylamino-1,1-diphenylpropoxy)-acetaldehyde diethyl acetal.

Workup

  1. customThe starting material is prepared
  2. washthe solution is washed successively with 2N aqueous sodium hydroxide and saturated aqueous sodium chloride
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-ddb710ed21314d919dec9673fa08b11a
Source dataset
uspto-grants-1977_03
Patent number
US04010166

Reaction notes

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