Hydrochloric Acid → 3-Bromo-2-Methoxyaniline hydrochloride

HRID 59623Notes

Reaction equation

HRID 59623 reaction equation
[Br:1][C:2]1[C:3]([O:9][CH3:10])=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[ClH:11]>C(OCC)(=O)C>[ClH:11].[Br:1][C:2]1[C:3]([O:9][CH3:10])=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 226677353-Bromo-2-methoxyaniline

Product 1

HCID 868104143-Bromo-2-Methoxyaniline hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of 3-bromo-2-methoxyaniline (10 g) in ethyl acetate (100 mL) was added concentrated hydrochloric acid (7 mL) at about room temperature. The reaction mixture was stirred for about 2 hours and filtered to give a solid, which was washed with ethyl acetate and dried at about 50° C. to about 55° C. Yield: 10 g

Workup

  1. filtrationfiltered
  2. customto give a solid, which
  3. washwas washed with ethyl acetate
  4. customdried at about 50° C. to about 55° C

Sources & evidence

ORD record
ord-e9c28f1da50f498aa7e55230dd189d25
Source dataset
uspto-grants-2016_09
Patent number
US09440927B2

Reaction notes

Loading…