1-(2-Pyrimidinyl)piperazine → 1-(2-Pyrimidyl)piperazine hydrochloride

HRID 596294Notes

Reaction equation

HRID 596294 reaction equation
[Cl:1]CC1C=CC2OC(C3C=CC=CC=3)OC=2C=1.[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>C1(C)C(C)=CC=CC=1>[ClH:1].[N:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 54430147HCID 54430147, compound

Product 1

HCID 28184571-(2-Pyrimidyl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 8.5 g (0.0344 mole) of 5-chloromethyl-2-phenyl benzo [d]-1,3-dioxole (BP/0.05 mm = 135°-137° C) and 11.3 g (0.0689 mole) of 1-(2-pyrimidinyl) piperazine in 250 ml of anhydrous xylene was refluxed for 9 hours. The precipitate of 1-(2-pyrimidinyl) piperazine hydrochloride formed was suction-filtered off and the xylene was evaporated off under reduced pressure.

Sources & evidence

ORD record
ord-380b7b33d57149dfa0429afb77893c1b
Source dataset
uspto-grants-1977_03
Patent number
US04010267

Reaction notes

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