Potassium Iodide → HCID 21437268、化合物

HRID 596371ノート

反応式

HRID 596371 の反応式
[I-].[K+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17]Cl)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1.[CH3:27][NH:28][CH2:29][CH:30]1[CH2:32][CH2:31]1>O1CCCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][N:28]([CH2:29][CH:30]4[CH2:32][CH2:31]4)[CH3:27])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1

参加物

5

反応物 3

HCID 4875Potassium IodideHCID 126123488-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepineHCID 12919209(Cyclopropylmethyl)methylamine

生成物 1

HCID 21437268HCID 21437268、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In the manner given in Preparation 29, potassium iodide and 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran are treated with methyl(cyclopropylmethyl)amine to give 8-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine. Preparation 31 8-Bromo-1-[[(cyclopropylemethyl)ethylamino]methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

出典と根拠

ORDレコード
ord-fb6b88cb407842cc85e1b26230298c5a
出典データセット
uspto-grants-1977_03
特許番号
US04010177

反応ノート

読み込み中…