Potassium Iodide → HCID 68120688, compound

HRID 596386Notes

Reaction equation

HRID 596386 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:24]=[CH:23][C:6]2[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[N:8][CH2:9][C:10]3[N:11]([C:12]([CH2:15]Cl)=[N:13][N:14]=3)[C:5]=2[CH:4]=1.[I-].[K+].[CH3:29][CH:30]=[CH:31][CH2:32][NH2:33]>O1CCCC1>[F:1][C:2]([F:26])([F:25])[C:3]1[CH:24]=[CH:23][C:6]2[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[N:8][CH2:9][C:10]3[N:11]([C:12]([CH2:15][NH:33][CH2:32][CH2:31][CH:30]=[CH2:29])=[N:13][N:14]=3)[C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 304472-Buten-1-amineHCID 21450803HCID 21450803, compound

Product 1

HCID 68120688HCID 68120688, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Preparation 39, 9-(trifluoromethyl)-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine, potassium iodide and methylallylamine in tetrahydrofuran are reacted to give 9-(trifluoromethyl)-1-[(allylmethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 48 8-Chloro-1-(pyrrolidinomethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-713ca653b7a24064997c34ebe5b2d899
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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