Potassium Iodide → HCID 21450818, compound

HRID 596389Notes

Reaction equation

HRID 596389 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16]Cl)=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:7]=2[CH:24]=1.[I-].[K+].[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>O1CCCC1>[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:7]=2[CH:24]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 31268PyrrolidineHCID 20291826HCID 20291826, compound

Product 1

HCID 21450818HCID 21450818, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Preparation 48, 8-(trifluoromethyl)-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, potassium iodide, and pyrrolidine in tetrahydrofuran are reacted to give 8-(trifluoromethyl)-1-(pyrrolidinomethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-9e14ac3f9322424ebdac99cb765295c0
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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