Allylamine → HCID 21450873, compound

HRID 596399Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:27])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]1[CH2:25]O.CS(OS(C)(=O)=O)(=O)=O.[CH2:37]([NH2:40])[CH:38]=[CH2:39]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:27])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]1[CH2:25][NH:40][CH2:37][CH:38]=[CH2:39]

Participants

Reactant 3

HCID 7853Allylamine

HCID 81560Methanesulfonic anhydride

HCID 21450871HCID 21450871, compound

Product 1

HCID 21450873HCID 21450873, compound

Procedure

In the manner given in Example 47, 2',5-dichloro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonic anhydride followed by allylamine to give 2',5-dichloro-2-[3-[(allylamino)methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-1afb428609954a6aaf511396d35f726f
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010177

Reaction notes

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