Methanesulfonyl chloride → HCID 21450841, compound

HRID 596404Notes

Reaction equation

HRID 596404 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25]O)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].CS(Cl)(=O)=O.[CH2:32]([NH2:35])[C:33]#[CH:34]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25][NH:35][CH2:32][C:33]#[CH:34])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 239041PropargylamineHCID 21450879[5-Chloro-2-[3-[(dimethylamino)methyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]phenyl]phenylmethanone

Product 1

HCID 21450841HCID 21450841, compound

Procedure

In the manner given in Example 47, 5-chloro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonyl chloride followed by propargylamine to give 5-chloro-2-[3-[[(2-propynyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-00d6dd83ac054661a5c3c5d987ee6d9f
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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