反应详情

温度

245 °C

To 4-cyanopyridine (4.2 g.) in methanol (60 ml.) is added sodium (0.2 g.). The solution is allowed to stand for 0.5 hour at room temperature and is then added to a suspension of p-aminobenzhydrazide (6.4 g.) in 150 ml. of methanol. The resulting solution is heated 20 hours at reflux during which time a solid separates. The solid is filtered and heated to 245° C. over 1 hour and maintained at that temperature for an additional 15 minutes. After cooling the solid is recrystallized from a mixture of acetonitrile and water to yield 3-(p-aminophenyl)-5-(4-pyridyl)-1,2,4-triazole (2 g.) m.p. 251°-252.5° C.

1. temperatureThe resulting solution is heated 20 hours
2. temperatureat reflux during which time a solid separates
3. filtrationThe solid is filtered
4. temperaturemaintained at that temperature for an additional 15 minutes
5. temperatureAfter cooling the solid
6. customis recrystallized from a mixture of acetonitrile and water