Tetrahydrofuran → HCID 21449481, compound

HRID 597008Notes

Reaction equation

HRID 597008 reaction equation
[CH3:1][C:2]1([CH:15]([CH3:17])[CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:13])[C:6]([Cl:12])=[C:7]([OH:11])[CH:8]=2)[C:3]1=[O:14].[H-].COCCO[Al+]OCCOC.[Na+].[H-].O1CCCC1>C1C=CC=CC=1>[CH3:1][C:2]1([CH:15]([CH3:17])[CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:13])[C:6]([Cl:12])=[C:7]([OH:11])[CH:8]=2)[CH:3]1[OH:14]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 12395586HCID 12395586, compoundHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

Product 1

HCID 21449481HCID 21449481, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Methyl-2-isopropyl-6,7-dichloro-1,5-indan-diol is prepared following substantially the same procedure described in Example 4, Step E, using the following substances: 2-methyl-2-isopropyl-5-hydroxy-6,7-dichloro-1-indanone (8.2 g., .03 mole); sodium bis-(2-methoxyethoxy)aluminum hydride (70% in benzene [10 ml.]; and tetrahydrofuran (100 ml.).

Sources & evidence

ORD record
ord-f555896eb91a4ddda5470c8fe4fec363
Source dataset
uspto-grants-1977_03
Patent number
US04012524

Reaction notes

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