2-Benzyl-2-methyl-5-hydroxy-6,7-dichloro-1-indanone → 2-Benzyl-2-methyl-6,7-dichloro-1,5-indandiol

HRID 597012Notes

Reaction equation

HRID 597012 reaction equation
[CH2:1]([C:8]1([CH3:21])[CH2:16][C:15]2[C:10](=[C:11]([Cl:19])[C:12]([Cl:18])=[C:13]([OH:17])[CH:14]=2)[C:9]1=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>O1CCCC1>[CH2:1]([C:8]1([CH3:21])[CH2:16][C:15]2[C:10](=[C:11]([Cl:19])[C:12]([Cl:18])=[C:13]([OH:17])[CH:14]=2)[CH:9]1[OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 123955912-Benzyl-2-methyl-5-hydroxy-6,7-dichloro-1-indanoneHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

Product 1

HCID 214494772-Benzyl-2-methyl-6,7-dichloro-1,5-indandiol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Benzyl-2-methyl-6,7-dichloro-1,5-indandiol is prepared following substantially the same procedure described in Example 4, Step E, using the following substances: 2-benzyl-2-methyl-5-hydroxy-6,7-dichloro-1-indanone (4.8 g., 0.015 mole); sodium bis-(2-methoxyethoxy)-aluminum hydride (70% in benzene [5 ml.]); and tetrahydrofuran (50 ml.).

Sources & evidence

ORD record
ord-a0c2eb9c40704229be72267ec89af33c
Source dataset
uspto-grants-1977_03
Patent number
US04012524

Reaction notes

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