Potassium Carbonate → HCID 21449487, compound

HRID 597020Notes

Reaction equation

HRID 597020 reaction equation
[CH:1]1([C:6]2([CH3:19])[CH2:14][C:13]3[C:8](=[C:9]([Cl:17])[C:10]([Cl:16])=[C:11]([OH:15])[CH:12]=3)[CH:7]2[OH:18])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31].[OH-].[Na+]>O.CN(C=O)C>[OH:18][CH:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[C:10]([Cl:16])[C:9]=2[Cl:17])[CH2:14][C:6]1([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)[CH3:19]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 76300Ethyl 4-bromobutyrateHCID 21449489HCID 21449489, compound

Product 1

HCID 21449487HCID 21449487, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

By following the procedure described in Example 4, Step F, using as the reagents 2-cyclopentyl-2-methyl-6,7-dichloroindan-1,5-diol (Example 5, Step C), (31 g., 0.1 mole), potassium carbonate (15.2 g., 0.11 mole), DMF (200 ml.), ethyl 4-bromobutyrate (23.5 g., 0.11 mole), water (200 ml.) and 10 N sodium hydroxide (40 ml.), there is obtained 4-(1-hydroxy-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)butyric acid.

Sources & evidence

ORD record
ord-27806c0c279845d2b4ffdfc31698a5bd
Source dataset
uspto-grants-1977_03
Patent number
US04012524

Reaction notes

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