Methylamine → HCID 86734557, compound

HRID 597054Notes

Reaction equation

HRID 597054 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[C:20]4[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=4)[C:14]([CH2:23][C:24]([O:26]C)=O)=[C:13]3[CH3:28])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:29][NH2:30]>CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[C:20]4[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=4)[C:14]([CH2:23][C:24]([NH:30][CH3:29])=[O:26])=[C:13]3[CH3:28])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 21449336HCID 21449336, compound

Product 1

HCID 86734557HCID 86734557, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 1-(7-chloroquinol-4-yl)-5-methoxy-2-methylindol-3-ylacetate (1.7g.) in methanol (50ml.) containing 30% w/v methylamine solution (25ml.) was refluxed for 10 hours. The solvents were evaporated in vacuo and the residue crystallised from a 1:1 v/v mixture of benzene and cyclohexane to give 1-(7-chloroquinol-4-yl)-5-methoxy-N,2-dimethylindol-3-ylacetamide, m.p. 168°-169° C.

Workup

  1. temperaturewas refluxed for 10 hours
  2. customThe solvents were evaporated in vacuo
  3. customthe residue crystallised from a 1:1 v/v mixture of benzene and cyclohexane

Sources & evidence

ORD record
ord-d8a5e0c2c6e74b2ea3357711643447a1
Source dataset
uspto-grants-1977_03
Patent number
US04012513

Reaction notes

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