反应详情

In the manner given in Example 26, 3-phthalimidobutyric acid and carbonyldiimidazol are reacted in tetrahydrofuran. To this mixture is added 7-chloro-2-hydrazino-(o-chlorophenyl)-3H-1,4-benzodiazepine to give 3-phthalimidobutyric acid, 2-[7-chloro-5-(o-chlorophenyl)3H-1,4-benzodiazepin-2-yl]hydrazide which is warmed with acetic acid to give N-[2-[8-chloro-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepin-1-yl]propyl]phthalimide.