Propylamine → HCID 21446379, compound

HRID 597097Notes

Reaction equation

HRID 597097 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:13]2[CH2:17][CH:16]([C:18](Cl)=[O:19])[CH2:15][C:14]2=[O:21])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[CH2:24]([NH2:27])[CH2:25][CH3:26]>C1C=CC=CC=1>[CH2:24]([NH:27][C:18]([CH:16]1[CH2:17][N:13]([C:5]2[CH:4]=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=2)[C:14](=[O:21])[CH2:15]1)=[O:19])[CH2:25][CH3:26]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 54086601HCID 54086601, compound

Product 1

HCID 21446379HCID 21446379, compoundYield 81.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3.59 g (0.01 mole) of the 1-(3,5-bis-trifluoromethylphenyl)-2-oxo-pyrrolidine-4-carboxylic acid chloride, produced according to Example 4, paragraph 1, is dissolved in 400 ml of benzene, and 1.2 g (0.02 mole) of N-n-propylamine is added to the solution. After subsequent processing as described in Example 4 there is obtained 3.1 g (81% of theory) of 1-(3,5-bis-trifluoromethylphenyl)-2-oxo-pyrrolidine-4-carboxylic acid-N-n-propylamide; m.p. 152.5° - 154° C. Analysis for C16H16F6N2O2 (molar weight 382.32):

Sources & evidence

ORD record
ord-8319f0934c7f4e9c9768e6161d3155c0
Source dataset
uspto-grants-1977_03
Patent number
US04013445

Reaction notes

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