Hydrochloric Acid → HCID 86734574, compound

HRID 597290Notes

Reaction equation

HRID 597290 reaction equation
[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([O:19]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:23][OH:24].C[O-].[Na+].Cl>O.CO>[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([NH:23][OH:24])=[O:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 70608017HCID 70608017, compound

Product 1

HCID 86734574HCID 86734574, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 5.0 g. of ethyl 3-phenyl-7-benzofuranacetate, 2.6 g. of hydroxylamine hydrochloride and 6.3 g. of sodium methoxide in 55 ml. of methanol is heated overnight at reflux. Water and dilute hydrochloric acid are added. The precipitate which forms is collected and recrystallized from ethanol to give 3-phenyl-7-benzofuranacethydroxamic acid, m.p. 163° (dec).

Workup

  1. additionA mixture of 5.0 g
  2. temperatureat reflux
  3. customThe precipitate which forms is collected
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a7083ad6aac74cea830b1cd0566eb2d0
Source dataset
uspto-grants-1977_03
Patent number
US04013692

Reaction notes

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