Cyclohexanethiol → HCID 21445072, compound

HRID 597462Notes

Reaction equation

HRID 597462 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7](Cl)[C:6]([N+:10]([O-:12])=[O:11])=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1)[CH3:2].[CH:17]1([SH:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>C(N(CC)CC)C>[CH2:1]([C:3]1[N:8]=[C:7]([S:23][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[C:6]([N+:10]([O-:12])=[O:11])=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 15290CyclohexanethiolHCID 21445066HCID 21445066, compound

Product 1

HCID 21445072HCID 21445072, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

12.1 g (50 m-moles) of 2-ethyl-4-chloro-5-nitro-6-isopropylamino-pyrimidine (vide Ex. 9a) are reacted with 7.0 g (60 m-moles) of cyclohexylmercaptan and 6.1 g (60 m-moles) of triethylamine to yield 12.0 g of 2-ethyl-4-cyclohexylthio-5-nitro-6-isopropylamino-pyrimidine of m.p. 69°-71° C.

Sources & evidence

ORD record
ord-a6a4cfb8082341159d2eacdb27d4361f
Source dataset
uspto-grants-1977_03
Patent number
US04014677

Reaction notes

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