Ethanol → Bis(diisopropylamino)chlorophosphine

HRID 597759Notes

Reaction equation

HRID 597759 reaction equation
P(Cl)(Cl)[Cl:2].C(NC(C)C)(C)C.[CH:12]([N:15]([PH:19][N:20]([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])[CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13].C(O)C>C1(C)C=CC=CC=1>[CH:24]([N:20]([P:19]([N:15]([CH:12]([CH3:14])[CH3:13])[CH:16]([CH3:17])[CH3:18])[Cl:2])[CH:21]([CH3:23])[CH3:22])([CH3:26])[CH3:25]

Participants

6

Reactant 4

HCID 702EthanolHCID 7912DiisopropylamineHCID 24387Phosphorus trichlorideHCID 498731Bis(diisopropylamino)-phosphine

Product 1

HCID 2733425Bis(diisopropylamino)chlorophosphine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Bis(diisopropylamino)chlorophosphine was synthesized by reacting phosphorous trichloride and diisopropylamine in toluene. Fifty ml of the resulting bis(diisopropylamino)phosphine was placed in a 250 ml flask and 3.01 ml of ethanol added slowly over a two minute period and the reaction allowed to proceed for several days. After filtering the mixture and removing the solvent, the structure of the bis(diisopropylamino)ethylphosphite ester reagent was analyzed by 31P and 1H NMR (31P NMR in CD3CN 125.9 ppm).

Workup

  1. waitto proceed for several days
  2. filtrationAfter filtering the mixture
  3. customremoving the solvent

Sources & evidence

ORD record
ord-091c74c35b4a4bfb922d1afbbb81ec01
Source dataset
uspto-grants-2011_03
Patent number
US07897338B2

Reaction notes

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