Hydrochloric Acid → 1-{3-[2-(1-Benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride

HRID 597808Notes

Reaction equation

HRID 597808 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[ClH:21]>C(OCC)(=O)C>[ClH:21].[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:17][CH:18]([OH:20])[CH2:19]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 235455641-(3-(2-(1-Benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol

Product 1

HCID 665884131-{3-[2-(1-Benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

0.28 g of 1-(3-(2-(1-benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol was dissolved in 3.0 ml of ethyl acetate. Thereafter, 0.35 ml of an ethyl acetate solution containing 3.25 mol/l dry hydrogen chloride was added to the obtained solution, and the obtained mixture was stirred at a room temperature for 1 hour. Subsequently, the solvent was distilled away under a reduced pressure, so as to obtain 0.30 g of a light yellow oil product, 1-(3-(2-(1-benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol hydrochloride.

Workup

  1. additionwas added to the obtained solution
  2. distillationSubsequently, the solvent was distilled away under a reduced pressure

Sources & evidence

ORD record
ord-a4524e4c31f2412f94eca085e7ab3368
Source dataset
uspto-grants-2011_03
Patent number
US07897594B2

Reaction notes

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