Hydrochloric Acid → (3R)-1-(2-(2-(1-benzothiophene-3-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride

HRID 597817Notes

Reaction equation

HRID 597817 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]2)=[CH:2]1.[ClH:21]>C(OCC)(=O)C>[ClH:21].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]2)=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58680085(3R)-1-(2-(2-(1-benzothiophene-3-yl)ethoxy)ethyl)-3-pyrrolidinol

Product 1

HCID 66588424(3R)-1-(2-(2-(1-benzothiophene-3-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

0.99 g of (3R)-1-(2-(2-(1-benzothiophene-3-yl)ethoxy)ethyl)-3-pyrrolidinol was dissolved in 5.0 ml of ethyl acetate. Thereafter, 1.10 ml of an ethyl acetate solution containing 3.25 mol/l dry hydrogen chloride was added to the obtained solution, and the obtained mixture was then stirred at a room temperature for 1 hour. Thereafter, the solvent was distilled away under a reduced pressure, so as to obtain 1.05 g of a light yellow oil product, (3R)-1-(2-(2-(1-benzothiophene-3-yl)ethoxy)ethyl)-3-pyrrolidinol hydrochloride.

Workup

  1. additionwas added to the obtained solution
  2. distillationThereafter, the solvent was distilled away under a reduced pressure

Sources & evidence

ORD record
ord-abb3ef420e804f1dbccc2ae0f7fcc672
Source dataset
uspto-grants-2011_03
Patent number
US07897594B2

Reaction notes

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