Hydrochloric Acid → 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine dihydrochloride

HRID 597822Notes

Reaction equation

HRID 597822 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH3:23])[CH3:22])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[ClH:24]>C(OCC)(=O)C>[ClH:24].[ClH:24].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH3:23])[CH3:22])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21990091HCID 21990091, compound

Product 1

HCID 219901571-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

0.39 g of 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine was dissolved in 4.0 ml of ethyl acetate. Thereafter, 0.80 ml of an ethyl acetate solution containing 3.25 mol/l dry hydrogen chloride was added to the obtained solution, and the mixture was stirred at a room temperature for 1 hour and then at 5° C. for 1 hour. Thereafter, precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate and then dried, so as to obtain 0.32 g of an achromatic crystal, 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-N,N-dimethyl-3-pyrrolidinamine dihydrochloride.

Workup

  1. additionwas added to the obtained solution
  2. waitat 5° C. for 1 hour
  3. customThereafter, precipitated crystals
  4. filtrationwere collected by filtration
  5. washThe crystals were washed with ethyl acetate
  6. customdried

Sources & evidence

ORD record
ord-7f0db751eea642768439a80fa868c622
Source dataset
uspto-grants-2011_03
Patent number
US07897594B2

Reaction notes

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