Potassium Carbonate → HCID 178509278, compound

HRID 59790Notes

Reaction equation

HRID 59790 reaction equation
Cl.[Br:2][C:3]1[CH:28]=[CH:27][C:6]([CH2:7][CH2:8][N:9]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.C([O-])([O-])=O.[K+].[K+].[C:35]([N:37]=[C:38]([N:40]1CCNCC1)[S-])#[N:36].O.[NH2:47]N>>[NH2:47][C:38]1[N:37]=[C:35]([N:13]2[CH2:14][CH2:15][CH:10]([N:9]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:24])=[O:25])=[CH:19][CH:18]=3)[CH2:8][CH2:7][C:6]3[CH:27]=[CH:28][C:3]([Br:2])=[CH:4][CH:5]=3)[CH2:11][CH2:12]2)[NH:36][N:40]=1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 24654Hydrazine hydrate (1:1)HCID 121410346HCID 121410346, compoundHCID 131737066N-cyanopiperazine-1-carbimidothioate

Product 1

HCID 178509278HCID 178509278, compound

Procedure

4-(((4-Bromophenethyl)(piperidin-4-yl)amino)methyl)benzenesulfonamide hydrochloride obtained in Step 2 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3.

Sources & evidence

ORD record
ord-32e6bbb94c12405cb58f08748b769f2c
Source dataset
uspto-grants-2016_09
Patent number
US09440953B2

Reaction notes

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