Methanol → HCID 23654008, compound

A mixture of 5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-amine (490 mg, 1.80 mmol), tBuNO2 (315 μl, 2.70 mmol), CuBr2 (481 mg, 2.20 mmol) and MeCN (10 ml) was heated to 70° C. for 5 h. The reaction mixture was parted between H2O and EtOAc, the organic layer was dried and then concentrated in vacuo. The resulting residue was purified by column chromatography to yield 100 mg (16%) of 3-bromo-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine. 1H-NMR (CDCl3) δ 8.46 (s, 1H), 7.64 (s, 1H), 4.25-3.20 (m, 7H), 1.39 (d, 1.3H), 1.35 (d, 1.65H) ppm. A mixture of 3-bromo-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine (90 mg, 267 μmol), K2CO3 (100 mg), MeOH (6 ml) and H2O (1 ml) was stirred for 16 h at room temprature. The reaction mixture was parted between aq. NaHCO3 and DCM, the organic layer was dried and then concentrated in vacuo. The resulting residue was purified by column chromatography to yield 25.0 mg (39%) of 3-bromo-5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine. 1H-NMR (MeOH-d4) δ 8.49 (s, 1H), 7.90 (s, 1H), 3.55-3.40 (m, 3H), 3.37-3.27 (m, 2H), 3.20 (dd, 1H), 3.11 (dd, 1H), 1.48 (d, 3H) ppm.

1. customthe organic layer was dried
2. concentrationconcentrated in vacuo
3. customThe resulting residue was purified by column chromatography

ORD record

ord-e59f0b6e911f443296bd3b6e76eb5b6b

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07897595B2