反应详情

To a mixture containing 0.70 g (5.5 mmol) of dimethyl sulfate and 0.25 g (4.5 mmol) of potassium hydroxide in 10 ml of tetrahydrofuran was added 0.5 g (2.25 mmol) of 5-Bromo-2-(methylthio)pyrimidin-4(3H)-one in portions over 15 min. After complete addition, the mixture was stirred overnight then diluted with ethyl acetate and washed with water. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via Biotage chromatography eluting with 20% ethyl acetate/dichloromethane gave 0.5 g (94%) of product.

1. additionAfter complete addition
2. washwashed with water
3. dry with materialThe organic phase was dried over magnesium sulfate
4. filtrationFiltration, removal of solvent and purification of the residue via Biotage chromatography
5. washeluting with 20% ethyl acetate/dichloromethane