Hydrochloric Acid → HCID 67266955, compound

HRID 598140Notes

Reaction equation

HRID 598140 reaction equation
[C:1]1([CH3:24])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[N:9]1[CH:13]=[CH:12][C:11]([C:14](OCC)=[O:15])=[C:10]1[C:19](OCC)=[O:20].O.[NH2:26][NH2:27].Cl>C(O)C>[C:1]1([CH3:24])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[N:9]1[C:10]2[C:19](=[O:20])[NH:26][NH:27][C:14](=[O:15])[C:11]=2[CH:12]=[CH:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 67266945HCID 67266945, compound

Product 1

HCID 67266955HCID 67266955, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of diethyl 1-mesityl-1H-pyrrole-2,3-dicarboxylate (3.4 g, 10.3 mmol), hydrazine monohydrate (2.0 ml, 41.3 mmol) and ethanol (20 ml) was heated under reflux for 48 hours. The mixture was acidified by addition of 5N hydrochloric acid and stirred at 80° C. for 20 min. After cooling, the crystals were collected by filtration to give 2.60 g (94%) of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. temperatureAfter cooling
  4. filtrationthe crystals were collected by filtration

Sources & evidence

ORD record
ord-538bb19fa4e9491b8aa9490171c4f3ce
Source dataset
uspto-grants-2011_03
Patent number
US07897607B2

Reaction notes

Loading…