Phosphorus oxychloride → HCID 67266688, compound

HRID 598197Notes

Reaction equation

[CH3:1][C:2]1[C:6]2[NH:7][C:8](=O)[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[N:4]([C:14]2[C:19]([Cl:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:15]=2[Cl:22])[N:3]=1.P(Cl)(Cl)([Cl:25])=O.C(N(CC)C(C)C)(C)C>>[Cl:25][C:8]1[N:9]([CH3:12])[C:10](=[O:11])[C:5]2[N:4]([C:14]3[C:19]([Cl:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:15]=3[Cl:22])[N:3]=[C:2]([CH3:1])[C:6]=2[N:7]=1

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 81531Diisopropylethylamine

HCID 67268202HCID 67268202, compound

Product 1

HCID 67266688HCID 67266688, compound

Conditions

Temperature: 100 °C

Procedure

A mixture of 3,6-dimethyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione (20 mg, 0.0556 mmol), phosphorus oxychloride (0.52 ml) and N,N-diisopropylethylamine (0.21 ml) was stirred at 100° C. for 60 h. The solvent was evaporated under vacuum to give the title compound, which was used for the next step without further purification.

Workup

customThe solvent was evaporated under vacuum

Sources & evidence

ORD record: ord-10dfe0e3c5fd4cbbb087cec6d0dcd572
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07897607B2

Reaction notes

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