反应详情

温度

75 °C

A mixture of 20 mg (0.05 mmol) [3-(6-Chloro-benzooxazol-2-ylamino)-pyrrolidin-1-yl]-(2,6-dimethoxy-phenyl)-methanone (example 1), 353 mg (2.48 mmol) methyliodid and 10 mg (0.075 mmol) K2CO3 in 0.5 mL DMF was stirred at 75° C. The mixture was concentrated, water and methanol was added and the mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid. The product containing fractions were evaporated to yield 9.6 mg (461%) of the title compound as light yellow solid. (MH+) 418.1.

1. concentrationThe mixture was concentrated
2. additionwater and methanol was added
3. customthe mixture was subjected to purification by preparative HPLC on reversed phase
4. washeluting with a gradient
5. customformed from acetonitrile, water and formic acid
6. additionThe product containing fractions
7. customwere evaporated