Trifluoroacetic acid → HCID 23146261, compound

HRID 598539Notes

Reaction equation

HRID 598539 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 86625768HCID 86625768, compound

Product 1

HCID 23146261HCID 23146261, compoundYield 29.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(RS)-2-Benzooxazol-2-ylmethyl-piperidine-1-carboxylic acid tert butyl ester (0.50 g) in dichloromethane (8 ml) was cooled (ice-bath) and trifluoroacetic acid (2 ml) added. The mixture was stirred with ice-cooling for 4 h, poured onto saturated potassium carbonate (20 ml) and extracted with dichloromethane. The combined extracts were dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.10 g)

Workup

  1. additionadded
  2. temperaturecooling for 4 h
  3. extractionextracted with dichloromethane
  4. dry with materialThe combined extracts were dried (MgSO4) and solvent
  5. customremoved at reduced pressure

Sources & evidence

ORD record
ord-b9c07dbaffa943f5b7778de76465845d
Source dataset
uspto-grants-2011_03
Patent number
US07897618B2

Reaction notes

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