Triethylamine → HCID 58779150, compound

HRID 598808Notes

Reaction equation

HRID 598808 reaction equation
[CH2:1]1[C:6](=O)N(OC(ON2C(=O)CCC2=O)=O)C(=O)[CH2:2]1.[CH3:19]CN(CC)CC.[O:26]1[CH2:30][CH2:29][C@H:28]([O:31][C:32](=[O:41])[O:33][N:34]2[C:38](=[O:39])[CH2:37][CH2:36][C:35]2=[O:40])[CH2:27]1>CC#N>[O:26]1[C:27]2([CH2:6][CH2:1][CH2:2][CH:28]2[O:31][C:32](=[O:41])[O:33][N:34]2[C:35](=[O:40])[CH2:36][CH2:37][C:38]2=[O:39])[CH2:19][CH2:29][CH2:30]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 676246Di(succinimido) carbonateHCID 11229944Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester

Product 1

HCID 58779150HCID 58779150, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The above spiro alcohol (27 mg, 0.19 mmol), N,N′-disuccinimidyl carbonate (52 mg, 0.204 mmol), Et3N (25 mg, 0.25 mmol) in CH3CN (5 mL) were stirred for 12 hours, following the same conditions as described for compound 22 to obtain compound 26 (22 mg, 40%). 1H NMR (CDCl3, 200 MHz): δ 4.7 (m, 1H), 3.8 (m, 2H), 2.8 (s, 4H), 1.5-2.1 (m, 10H).

Sources & evidence

ORD record
ord-efdccfbb583942fc9e47927dc687f476
Source dataset
uspto-grants-2011_03
Patent number
US07897635B2

Reaction notes

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